Injection to kill cancer cells?

“Two years with you, you will be 26 years old. It’s my turn this time?”
“I haven’t been shaking my mark for a year, I would like to change my luck with my ex boyfriend’s happiness for the next half of my life!”
To say that the hottest vaccine in July, except for the new crown vaccine, is the HPV vaccine. 430000 people in Shenzhen have been nicknamed, and only 10000 people have been signed in the end. As a cancer vaccine, HPV vaccine plays a great role in the prevention of cervical cancer. In fact, cancer vaccine, not only the use of prevention, but also the use of treatment.
Cancer vaccines can be divided into preventive vaccines and therapeutic vaccines. By injecting cancer vaccines, the immune system can “command” to discover or destroy cells or viruses harmful to human body.
Cancer vaccine originated from “corytoxin”
Therapeutic vaccines are one of immunotherapy, and all of them can be traced back to the 19th century “father of cancer immunotherapy” William Coley’s crazy medical experiments
In the 1990s, Dr. William Coley discovered that a late cancer patient accidentally infected with Streptococcus, and then the tumor disappeared. The discovery was so exciting that he made a mixture of bacteria himself and injected it into cancer patients, a substance called Colin, which causes infection in the body, triggering the patient’s immune system. After that, the immune system not only attacked bacterial infection, but also attacked cancer cells.
This is the origin of human exploration of immunotherapy. Although Koli treated some patients, because of his thought was too advanced at that time, no one could understand his idea, and he himself could not explain the effective principle of “coritoxin” for cancer. Therefore, he was also regarded as a madman by the medical community. It was not until the 1980s that the medical community understood, “Koliatoxin” is to “kill” cancer cells by relying on the immune system.
Activate the immune system and destroy cancer cells
Nowadays, with the development of immunology, the research of cancer vaccine has entered a new period. The current cancer vaccine is mainly divided into preventive and therapeutic.
Preventive vaccines can prevent some cancers caused by viruses, and achieve the prevention goal by protecting human body from virus. At present, preventive vaccines include HPV vaccine and hepatitis B vaccine, which are used to prevent viruses such as cervical cancer and liver cancer.
Therapeutic vaccine is a treatment method of immunotherapy. It is aimed at the cancer patients who have already been ill. Generally speaking, cancer specific antigen molecules will be on the surface of cancer cells. Normal cells of human body do not carry such molecules. They are transmitted to the human body through injection of vaccine, and “inform” the immune system that this is antigen, The immune system then actively looks for and attacks cancer cells with antigen molecules.
In general, therapeutic vaccines enhance the ability of the human body to detect and destroy antigens, especially for cancer specific antigen molecules, which can trigger the immune system of the human body, and then let the immune cells destroy those cancer cells.
Latest progress: Chinese experts have developed a new personalized nano tumor vaccine
The research and exploration of cancer vaccine in China has never stopped. On July 7 this year, the sub Journal of science translation medicine, affiliated to science, published the latest research by Nie Guangjun, researcher Wu Yan and academician zhaoyuliang of China nano science center.
Researchers have integrated the plasma membrane of E.coli cells and the membrane of autogenous tumor cells into nanoparticles, and then developed a new cancer vaccine. The survival rate of mice was improved and the mice were protected from the repeated attack of cancer cells.
In the mouse models of colorectal cancer, melanoma and breast cancer, the relevant experiments showed that the vaccine could induce strong specific anti-tumor immune response, inhibit tumor recurrence and induce tumor disappearance.
Although the related experiments still stay in the animal experiment stage, the research shows that personalized cancer vaccine in the future has great potential for the treatment and prevention of tumor recurrence.
Global therapeutic vaccines are blooming everywhere, and they will be available in the future
In clinical, there are many therapeutic vaccines in play their due role.
Lung cancer vaccine
The EGF vaccine of Cuba has been available for many years. According to the data of phase III clinical trials, the median OS of the vaccine is 12.43 months, which is better than that of chemotherapy for 9.43 months.
Breast cancer vaccine
The United States has successfully developed HER2 vaccine and has opened clinical trials. Phase one clinical trial showed that patients with breast cancer were well tolerated without serious adverse effects. The two phase of clinical trials also showed that the vaccine improved overall survival rate in HER-2 positive breast cancer patients, and tolerated well and had mild adverse reactions. At present, the third phase of clinical trials is in the process of development.
Colorectal cancer vaccine
Oncovax vaccine has been successfully developed and entered the clinical trial stage for the recurrence of colorectal cancer. The data showed that the vaccine significantly prolonged the recurrence free period of colorectal cancer patients in three stages, and the total recurrence risk and death risk were significantly reduced. During the 5.8-year median follow-up, the recurrence free period and median survival period were prolonged.
According to the current research trend, therapeutic vaccines will play a great role in the field of cancer in the future. For cancer patients, the new treatment method not only improves the possibility of cure, but also improves the confidence of survival. It should be seen.

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