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Norditropin® is a prescription medicine that contains human growth hormone and is used to treat
Norditropin Nordilet: composition, indications, dosage, side effects
This drug is a group of drugs that belong to the group of drugs based on hormones secreted by the anterior pituitary gland – the gland from the discharge of the endocrine glands, which is located at the base of the skull.
The drug consists of the human hormone somatropin (recombinant growth hormone) – a protein secreted by bacterial E.coli cells. Among the genes of these bacteria is one that contains the encoded growth rate of a given organism.
Also, somatropin hormone affects both the rate at which a person grows, but also his metabolism, including carbohydrate (causes an increase in blood glucose levels), body anatomy, homeostasis, and learning. It mainly affects the growth of tubular bones located in the limbs.
Particularly effective when injected, reaching maximum values after 4 hours after administration.
Composition and release form Main active substance: somatropin. Included in the preparation of excipients: mannitol, histidine, poloxamer, phenol, water for injection. Available in the form of an injection solution, in a syringe handle, in a dosage of 10 mg of somatropin, 3 IU of substance per 1 mg of somatropin.
Indications This drug is used to treat short stature in children with hypopituitarism (growth hormone deficiency) and Turner syndrome.
Contraindications Consider the drug is contraindicated to apply in cases where the patient has severe hypersensitivity ( allergy ) to the main or to one of the auxiliary components.
Contraindicated use when closing the epiphyses (cessation of bone growth), cancer In children with chronic kidney disease before kidney transplantation, treatment with this drug should be discontinued.
With caution used in diabetes (possible attacks of hypoglycemia), hypothyroidism, increased intracranial pressure, intracranial hypertension.
Use during pregnancy and lactation This drug is contraindicated in the treatment of pregnant women.
If it is necessary to take the drug during breastfeeding, lactation is suspended.
Dosage and administration The drug is injected (subcutaneously and intramuscularly), under the constant supervision of an experienced physician with experience in diagnosing and treating patients with growth hormone deficiency.
The recommended weekly dose for growth hormone deficiency is from 0.6-07 IU / kg body weight to 1.0 IU / kg body weight.
The dosage is divided into 6-7 identical parts and is administered subcutaneously or intramuscularly in the evening.
With sustained edema or severe paresthesia, the dose of the drug is reduced to avoid the development of carpal tunnel syndrome. To prevent the development of lipoatrophy injection site must be changed.
Overdose Overdose can cause a sharp decrease in the level of insulin in the blood (the phenomenon of hypoglycemia). Then the sugar level rises sharply and hyperglycemia may develop.
In chronic overdose, gigantism or acromegaly can develop. Other effects that may occur with an excessive dose of growth hormone may also occur. In case of overdose, treat symptoms.
Side effects The drug is usually well tolerated. Side effects may occur in the form of:
– hypersensitivity reactions;
– itching, redness may occur at the injection site; – hypothyroidism. In some cases, if small growth is caused by a deletion in the gene complex of growth hormone, treatment with somatropin can lead to the body producing antibodies that inhibit the growth process.
In this case, epiphyseolysis may occur, accompanied by a lesion of the hip joint. A child with a limp of unexplained genesis should be examined.
Terms and conditions of storage The shelf life is up to 2 years from the production date printed on the package.
Storage temperature should not be lower than 2 and not higher than 8 A C.
15mg/45iu x 1 cartridge, 15mg/45iu x 5 cartridge, 15mg/45iu x 10 cartridge, 10mg/30iu x 1 cartridge, 10mg/30iu x 5 cartridge, 10mg/30iu x 10 cartridge